Chemical and Physical Tests

SGS performs USP/NF chemical and physical tests on a wide variety of raw materials and finished products. ACS, BP, EP and JP compendial procedures are also available.

All testing is performed in strict accordance with procedure details. Fees generally apply to basic compendial test procedures but may also change due to:

• Materials and procedures requiring special handling
• USP revisions

Commonly performed tests:

• Acid Value
• Alcohol Assay  – Gas Chromatography
  • 1 sample
  • additional samples, concurrently submitted
• Alginates Assay
• Arsenic Limit Test  – Method I
• Arsenic Limit Test – Method II
• Container Tests
• Conductivity
• Congealing Temperature
• Disintegration Test  – uncoated or plain coated tablets
• Disintegration Test – other tablets and capsules
• Dissolution  – Stage I, Spectroscopy, 6 kettles
  • initial assay, minimum
  • additional assays
• Dissolution – Stage I, HPLC, 6 kettles
  • initial assay, minimum
  • additional assays
• Distilling Range
• Metals  – Method I
• Heavy Metals – Method II
• Heavy Metals – Method III
• Heavy Metals Screen by ICP-OES (Pharmacopeial Forum Method, Volume 30 (6)
• Elements: Sb, As, Bi, Cd, In, Pb, Hg, Mo, Pd, Pt, Ru, Se, Ag, Sn (quantitative results)
  • ICP-OES set-up
• Sample Analysis
• Hydroxyl Value
• Iodine Value
• Iron
• Lead Limit Test  – with sample digestion
• Lead Limit Test – without sample digestion
• Loss on Drying
• Loss on Ignition
• Melting Point or Range – Class I or Ia
• Melting Point or Range – Class II
• Nitrogen  – Kjeldahl – Method I
• Nitrogen – Kjeldahl – Method II
• Nitrogen Gas Testing
• Optical Rotation
• Ordinary Impurities
• Organic Volatile Impurities  – Method I
• Organic Volatile Impurities – Method IV
• Organic Volatile Impurities – Method V
• Particulate Matter in Injections  – Light Obscuration Method
  • liquids (per sample or sample composite)
  • powders (per sample or sample composite)
• sample composition for particulate analysis
• Particulate Matter in Injections – Microscopic Method
  • 1 sample
  • 2+ samples
• Particulate Matter in Water
• Peroxide Value
• pH
• Readily Carbonizable Substances
• Refractive Index
• Residue on Ignition
• Saponification Value
• Selenium Limit Test
• Specific Gravity
• Total Organic Carbon (TOC)
• Viscosity  – Brookfield
• Viscosity – Capillary
• Water – Method I (Karl Fischer)
• Water – Method II (Azeotropic – Toluene Distillation)
• Water – Method III (Gravimetric)
• USP Purified Water Monograph (conductivity and TOC)
• USP Sterile Purified Water (pH, ammonia, calcium, CO2, chloride, sulfate, oxidizable substances)
• USP Water for Injection Monograph (conductivity and TOC)

Please contact our Chemical and Physical Test Experts for more information about the tests not listed above or fill out our Request for Quotation form.